Computational Systems Analysis of the Glycolytic Pathway in Lactococcus lactis
نویسنده
چکیده
Short Abstract — The goal of this study is to develop a comprehensive kinetic-dynamic model of the control of carbohydrate metabolism in Lactococcus lactis under anaerobic conditions. We have incorporated the dynamic peak and consumption behavior of the intermediate metabolite Fructose1,6-bisphosphate (FBP) for varying amounts of environmental glucose concentrations in this model. This comprehensive model will be expanded and fine-tuned to account for pH effects and utilized to create acid-resistant Lactococcus strains which have the potential of being used as a novel vehicle for the non-invasive delivery of vaccines and therapeutic proteins.
منابع مشابه
Glycolysis and the regulation of glucose transport in Lactococcus lactis spp. lactis in batch and fed-batch culture
BACKGROUND Despite the fact that many reports deal with glycolysis in Lactococcus lactis, there is not much information on the regulation of uptake of glucose itself. The aim of the present work was to investigate the effect of the glucose level on its specific uptake rate. RESULTS Studies on aeration levels in pH controlled L. lactis spp. lactis batch cultures on glucose (55 mM) showed that ...
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تاریخ انتشار 2012